Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964846 | 0.94 | GAA (0.65) | GAAL3MBTL1TEAD1EPHX1LMNA | |
| SCHEMBL5527608 | 0.94 | GAA (0.65) | GAAL3MBTL1TEAD1EPHX1LMNA | |
| SCHEMBL14964842 | 0.94 | GAA (0.65) | GAAL3MBTL1TEAD1EPHX1LMNA | |
| SCHEMBL30672690 | 0.91 | GAA (0.55) | GAAL3MBTL1TEAD1EPHX1LMNA | |
| SCHEMBL16217914 | 0.82 | GAA (0.60) | GAAL3MBTL1TEAD1EPHX1LMNA | |
| SCHEMBL4214716 | 0.82 | GAA (0.69) | GAAL3MBTL1KCNH2HRH3 | |
| SCHEMBL664938 | 0.81 | GAA (0.85) | GAAL3MBTL1EPHX1LMNARECQL | |
| SCHEMBL27818229 | 0.81 | GAA (0.85) | GAAL3MBTL1EPHX1LMNARECQL | |
| SCHEMBL510133 | 0.79 | GAA (0.44) | GAAL3MBTL1EPHX1LMNARECQL | |
| SCHEMBL14342621 | 0.78 | L3MBTL1 (0.57) | GAAL3MBTL1EPHX1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892899-A1 | IMIDAZOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | Bristol-Myers Squibb Company (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039595-A1 | IMIDAZOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-13 | — | — | WO | disclosed |