Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.69 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | EEF2K | O00418 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552561 | 1.00 | MAOB (0.69) | MAOBAKR1B10TTRAKR1B1ALDH1A1 | |
| SCHEMBL1552825 | 0.88 | MAOB (0.63) | MAOBTTRALDH1A1MAPTGSK3B | |
| SCHEMBL1552823 | 0.88 | MAOB (0.63) | MAOBTTRALDH1A1MAPTGSK3B | |
| SCHEMBL1551530 | 0.81 | MAOB (0.60) | MAOBALDH1A1MAPTSMN1; SMN2EGFR | |
| SCHEMBL1551528 | 0.81 | MAOB (0.60) | MAOBALDH1A1MAPTSMN1; SMN2EGFR | |
| Ls-104 SCHEMBL3956490 | 0.80 | MAOB (1.00) | MAOBALDH1A1MAPTRECQLSMN1; SMN2 | |
| Ls-104 SCHEMBL3956495 | 0.80 | MAOB (1.00) | MAOBALDH1A1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL13678405 | 0.79 | MAOB (0.62) | MAOBTTRALDH1A1MAPTRECQL | |
| SCHEMBL6915091 | 0.79 | MAOB (0.68) | MAOBAKR1B10TTRAKR1B1ALDH1A1 | |
| SCHEMBL6915100 | 0.79 | MAOB (0.68) | MAOBAKR1B10TTRAKR1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467967-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2011-04-27 | — | — | EP | claimed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | claimed |
| US-20070197660-A1 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-23 | — | — | US | claimed |
| EP-1654220-A4 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2006-10-25 | — | — | EP | claimed |
| EP-1654220-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | The Hospital for Sick Children (CA) | 2006-05-10 | — | — | EP | claimed |
| US-20050085538-A1 | Compounds for modulating cell proliferation | HOSPITAL FOR SICK CHILDREN, THE (CA) | 2005-04-21 | — | — | US | claimed |
| WO-2005012234-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2005-02-10 | — | — | WO | claimed |
| EP-1467967-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | The Hospital for Sick Children (CA) | 2004-10-20 | — | — | EP | claimed |
| WO-2003062190-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-07-31 | — | — | WO | claimed |
| EP-1467967-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2011-04-27 | — | — | EP | disclosed |
| EP-1467967-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2011-04-27 | — | — | EP | disclosed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | disclosed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | disclosed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | disclosed |
| EP-1551381-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | The Hospital for Sick Children (CA) | 2005-07-13 | — | — | EP | disclosed |
| US-20050085538-A1 | Compounds for modulating cell proliferation | HOSPITAL FOR SICK CHILDREN, THE (CA) | 2005-04-21 | — | — | US | disclosed |
| WO-2005012234-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2005-02-10 | — | — | WO | disclosed |
| EP-1467967-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | The Hospital for Sick Children (CA) | 2004-10-20 | — | — | EP | disclosed |
| WO-2004032911-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-04-22 | — | — | WO | disclosed |
| WO-2003062190-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085538-A1 | Compounds for modulating cell proliferation | CCNO, CCNY, CCND3 | MAOB 1268/4885AKR1B10 592/4885TTR 4684/4885 |
| US-20070197660-A1 | Compounds for modulating cell proliferation | CCND3, CCNO, WNT3 | MAOB 2008/4885AKR1B10 790/4885TTR 4432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.