WNT3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4615862	1.00	19/20
SCHEMBL4675026	1.00	19/20
SCHEMBL4675033	1.00	19/20
SCHEMBL4615676	0.87	19/20
SCHEMBL4616363	0.87	19/20
SCHEMBL4617199	0.75	19/20
SCHEMBL4731423	0.59	19/20
SCHEMBL4618396	0.72	18/20
SCHEMBL4617933	1.00	17/20
SCHEMBL4616756	0.75	17/20
SCHEMBL4616032	0.85	16/20
SCHEMBL4636587	0.83	16/20
SCHEMBL4638275	0.71	16/20
SCHEMBL4638972	0.70	16/20
SCHEMBL4615733	0.81	15/20
SCHEMBL4637352	0.63	15/20
SCHEMBL4637349	1.00	14/20
SCHEMBL4617286	1.00	13/20
SCHEMBL4617290	1.00	13/20
SCHEMBL4731974	0.87	13/20

Clinical trials — most relevant to WNT3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
CAR-T Cell Therapy Targeting GPC3 in Patients with Advanced GPC3-Positive Hepatocellular Carcinoma	PHASE1/PHASE2	NOT_YET_RECRUITING
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
Mesalazine Effects in Sporadic Colorectal Adenoma Patients	PHASE2	COMPLETED
Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel	PHASE2	NOT_YET_RECRUITING
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of XNW7201 in Subjects With Advanced Solid Tumors	PHASE1	COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC)	PHASE1	COMPLETED
Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma	EARLY_PHASE1	RECRUITING
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Klotho _ LRP-6 _ Gastric Adenocarcinoma	nan	UNKNOWN
Tension-Type Headache Gene Expression and Methylation	nan	AVAILABLE
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Eosinophil Induced Remodelling in Asthma	nan	COMPLETED
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma.	nan	RECRUITING
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling	nan	COMPLETED
Glypican-3 as a Prognostic Factor in Patients With Hepatocellular Carcinoma Treated by Immunotherapy	nan	RECRUITING
Biomarkers in Samples From Patients With Endometrial Cancer	nan	WITHDRAWN
CircularRNA-microRNA-mRNA Regulatory Axis in IVF	nan	NOT_YET_RECRUITING
Role of CTHRC1 in Diagnosis of Rheumatoid Arthritis	nan	UNKNOWN
DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CAD	nan	UNKNOWN
Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma	nan	ACTIVE_NOT_RECRUITING
CTNNB1 Neurodevelopmental Syndrome - Natural History Study	nan	RECRUITING
Diagnostic and Therapeutic Targets in Cartilaginous Tumours	nan	RECRUITING
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients	nan	UNKNOWN
Unusual Infiltrative Patterns of Malignant Cells in Endometrial Carcinoma and Immunohistochemical Expression of P53	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a WNT3 binder may also engage these)

Protein	Name	Similarity
P17553	—	1.000	P17553 →
WNT3A	Protein Wnt-3a	0.987	landscape →
Q2LMP1	—	0.987	Q2LMP1 →
P27467	—	0.987	P27467 →
P31285	—	0.953	P31285 →
P31284	—	0.919	P31284 →
Q9JIB4	—	0.917	Q9JIB4 →
Q6P1K8	—	0.917	Q6P1K8 →
GLS	Glutaminase kidney isoform, mitochondrial	0.915	landscape →
Q13888	—	0.915	Q13888 →
ERBB4	Receptor tyrosine-protein kinase erbB-4	0.915	landscape →
Q2TBV5	—	0.914	Q2TBV5 →
KCNT1	Potassium channel subfamily T member 1	0.913	landscape →
Q9GKY0	—	0.913	Q9GKY0 →
D3Z7P3	—	0.913	D3Z7P3 →
Q9UNW1	—	0.913	Q9UNW1 →
Q6UXG2	—	0.912	Q6UXG2 →
Q5R9Y1	—	0.912	Q5R9Y1 →
Q62956	—	0.911	Q62956 →
A0JN27	—	0.911	A0JN27 →
Q12841	—	0.910	Q12841 →
Q58D84	—	0.910	Q58D84 →
Q61527	—	0.910	Q61527 →
Q76LW2	—	0.909	Q76LW2 →
Q5R890	—	0.909	Q5R890 →
P13264	—	0.907	P13264 →
Q4W5Z4	—	0.907	Q4W5Z4 →
Q7RTP6	—	0.905	Q7RTP6 →
Q9WV18	—	0.904	Q9WV18 →
Q5SP67	—	0.904	Q5SP67 →