Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 15/20 | 0.69 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CLK3 | P49761 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552337 | 0.95 | CHEK2 (0.69) | CHEK2BRD4PARP1PARP2 | |
| SCHEMBL1552362 | 0.90 | CHEK2 (0.70) | CHEK2 | |
| SCHEMBL1552375 | 0.88 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL1553042 | 0.86 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL1552686 | 0.86 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL21017876 | 0.86 | CHEK2 (0.65) | CHEK2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL1551686 | 0.85 | CHEK2 (0.72) | CHEK2 | |
| SCHEMBL1553018 | 0.84 | CHEK2 (0.72) | CHEK2 | |
| SCHEMBL1551758 | 0.83 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL1552318 | 0.82 | CHEK2 (0.73) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824832-B1 | ARYL-SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE ETHERS AS ANTI-CANCER AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-27 | — | — | EP | claimed |