Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.33 |
| ▸ | PDE1A | P54750 | 3/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397564 | 0.81 | PDE1C (0.32) | PDE1CPDE1APDE1B | |
| SCHEMBL1442435 | 0.68 | — | — | |
| SCHEMBL2616540 | 0.65 | HSD11B1 (0.69) | HSD11B1PDE1CPDE1APDE1B | |
| SCHEMBL22653026 | 0.65 | CHRNA7 (0.42) | — | |
| SCHEMBL593295 | 0.64 | TNK2 (0.40) | — | |
| SCHEMBL12086449 | 0.64 | HSD11B1 (0.53) | HSD11B1PDE1CPDE1APDE1B | |
| SCHEMBL16748915 | 0.62 | TNK2 (0.37) | — | |
| SCHEMBL19264066 | 0.62 | TNK2 (0.39) | — | |
| SCHEMBL25221946 | 0.61 | PDE1C (0.43) | SSTR4PDE1CPDE1APDE1B | |
| SCHEMBL28588947 | 0.61 | SSTR4 (0.39) | SSTR4PDE1CPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951724-B1 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARM INC (US) | 2011-04-27 | — | — | EP | disclosed |