Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 15/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328848 | 0.81 | BRD4 (0.72) | BRD4BRD2SMARCA2BRD3BRDT | |
| SCHEMBL15328558 | 0.74 | BRD4 (0.66) | BRD4BRD2SMARCA2BRD3BRDT | |
| SCHEMBL7680896 | 0.69 | BRD4 (0.65) | BRD4MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL1553699 | 0.67 | MAPT (0.57) | BRD4CYP19A1MEN1KMT2ALMNA | |
| SCHEMBL7885154 | 0.66 | MAPT (0.56) | BRD4CYP19A1MEN1KMT2ALMNA | |
| SCHEMBL7813399 | 0.66 | MEN1 (0.72) | CYP19A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL16547978 | 0.65 | BRD4 (0.50) | BRD4MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL7885152 | 0.65 | MAPT (0.54) | BRD4CYP19A1MEN1KMT2ALMNA | |
| SCHEMBL28337651 | 0.65 | MEN1 (0.54) | CYP19A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL4029870 | 0.65 | PDE7A (0.73) | CYP19A1MEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838881-A1 | ISOINDOLONE DERIVATIVES | AbbVie Inc. (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013155695-A1 | ISOINDOLONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-10-24 | — | — | WO | disclosed |