Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.81 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386623 | 0.92 | HDAC6 (0.77) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6384657 | 0.90 | HDAC6 (0.75) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2227202 | 0.90 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2226798 | 0.90 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2227725 | 0.90 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2224837 | 0.88 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2226000 | 0.86 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28215034 | 0.86 | HDAC6 (0.62) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2447478 | 0.86 | HDAC6 (0.62) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8641718 | 0.86 | HDAC6 (0.59) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2839037-A1 | BIOMARKERS TO IDENTIFY PATIENTS THAT WILL RESPOND TO TREATMENT AND TREATING SUCH PATIENTS | Acetylon Pharmaceuticals, Inc. (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013158984-A1 | BIOMARKERS TO IDENTIFY PATIENTS THAT WILL RESPOND TO TREATMENT AND TREATING SUCH PATIENTS | ACETYLON PHARMACEUTICALS, INC. (US) | 2013-10-24 | — | — | WO | disclosed |