Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28215034 | 1.00 | HDAC6 (0.62) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL1232674 | 0.94 | HDAC6 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL15525296 | 0.86 | HDAC6 (0.81) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10906612 | 0.84 | HDAC6 (0.50) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10903602 | 0.79 | HDAC3 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL6386623 | 0.78 | HDAC6 (0.77) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2227202 | 0.77 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL6384657 | 0.77 | HDAC6 (0.75) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2226798 | 0.76 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2227725 | 0.76 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544673-A1 | THIOXANTHONE-BASED AUTOPHAGY INHIBITOR THERAPIES TO TREAT CANCER | Spectrum Pharmaceuticals, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112623-A1 | THIOXANTHONE-BASED AUTOPHAGY INHIBITOR THERAPIES TO TREAT CANCER | SPECTRUM PHARMACEUTICALS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |