Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.58 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.57 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.57 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.57 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 7/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.69 |
| ▸ | DRD1 | P21728 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464377 | 0.99 | DRD2 (0.70) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL1692381 | 0.82 | DRD2 (1.00) | DRD2DRD3HTR1ADRD1KDM4E | |
| Bromide SCHEMBL11708330 | 0.79 | KDM4E (0.78) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL2554856 | 0.78 | DRD2 (0.72) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL30004318 | 0.78 | DRD2 (0.72) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL3265051 | 0.78 | DRD2 (0.72) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL29506709 | 0.78 | KDM4E (0.80) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL29467728 | 0.78 | KDM4E (0.80) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL4159150 | 0.78 | KDM4E (0.80) | DRD2DRD3HTR1ADRD1KDM4E | |
| SCHEMBL3936482 | 0.78 | KDM4E (0.80) | DRD2DRD3HTR1ADRD1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844756-A1 | MODULATING IMMUNE RESPONSES | Barber, Glen N. (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166000-A1 | MODULATING IMMUNE RESPONSES | BARBER GLEN N (US) | 2013-11-07 | — | — | WO | disclosed |