Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.52 |
| ▸ | JAK2 | O60674 | 13/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15529081 | 0.91 | JAK1 (0.42) | JAK1JAK2MEN1KMT2A | |
| SCHEMBL20753927 | 0.78 | JAK1 (0.56) | JAK1JAK2 | |
| SCHEMBL15529320 | 0.77 | — | — | |
| SCHEMBL15529128 | 0.77 | ALDH1A1 (0.39) | JAK1JAK2 | |
| SCHEMBL20744346 | 0.76 | JAK1 (0.55) | JAK1JAK2MEN1KMT2A | |
| SCHEMBL15529321 | 0.76 | ALDH1A1 (0.40) | — | |
| SCHEMBL20753934 | 0.75 | JAK1 (0.63) | JAK1JAK2 | |
| SCHEMBL22328951 | 0.72 | JAK1 (0.54) | JAK1JAK2MEN1KMT2A | |
| SCHEMBL20754050 | 0.72 | JAK1 (0.48) | JAK1JAK2MEN1KMT2A | |
| SCHEMBL16228166 | 0.71 | NAMPT (0.53) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | claimed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |