Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15530184 | 0.92 | NPC1 (0.61) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15528784 | 0.89 | NAMPT (0.61) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15529003 | 0.89 | NAMPT (0.61) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15528993 | 0.88 | NAMPT (0.60) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15529611 | 0.88 | NAMPT (0.56) | NAMPTGRIN2BCYP3A4 | |
| SCHEMBL15529761 | 0.87 | NAMPT (0.59) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15529185 | 0.86 | NAMPT (0.64) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15528801 | 0.86 | CYP3A4 (0.59) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15529481 | 0.86 | NAMPT (0.58) | NAMPTGRIN2BCYP3A4NPC1RAB9A | |
| SCHEMBL15529251 | 0.86 | NAMPT (0.61) | NAMPTGRIN2BCYP3A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | claimed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |