Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | NAMPT | P43490 | 10/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15529208 | 0.93 | NAMPT (0.69) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL15528763 | 0.93 | NAMPT (0.63) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL15529249 | 0.91 | CYP3A4 (0.58) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL15528998 | 0.89 | NAMPT (0.57) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL15528943 | 0.89 | NAMPT (0.58) | CYP3A4NAMPT | |
| SCHEMBL15528784 | 0.87 | NAMPT (0.61) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL15529493 | 0.87 | NAMPT (0.59) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL16219016 | 0.87 | CYP11B2 (0.49) | CYP3A4NAMPTLMNA | |
| SCHEMBL15529997 | 0.86 | NAMPT (0.62) | CYP3A4NAMPTGRIN2BLMNASMN1; SMN2 | |
| SCHEMBL16228537 | 0.86 | NAMPT (0.58) | CYP3A4NAMPTGRIN2BSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296723-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2016-03-29 | — | — | US | claimed |
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | claimed |
| US-20140336168-A1 | NAMPT INHIBITORS | ABBVIE INC. | 2014-11-13 | — | — | US | claimed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |
| US-9758511-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160168134-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2016-06-16 | — | — | US | disclosed |
| US-9296723-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2016-03-29 | — | — | US | disclosed |
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | disclosed |
| US-20140336168-A1 | NAMPT INHIBITORS | ABBVIE INC. | 2014-11-13 | — | — | US | disclosed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168134-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | CYP3A4 4662/4885NAMPT 1/4885GRIN2B 1070/4885 |
| US-20140336168-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | CYP3A4 4662/4885NAMPT 1/4885GRIN2B 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.