Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.69 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.69 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.69 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.69 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410317 | 0.85 | GABRG2 (0.79) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL249109 | 0.82 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL29469733 | 0.82 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6772680 | 0.80 | GABRG2 (0.72) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL248296 | 0.80 | GABRG2 (0.88) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL29528203 | 0.80 | GABRG2 (0.88) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2759466 | 0.79 | GABRG2 (0.90) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6772674 | 0.79 | GABRG2 (0.75) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2654038 | 0.78 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL247567 | 0.76 | GABRG2 (0.88) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013170243-A1 | FORM 5 POLYMORPH OF 7-(TERT-BUTYL-D9)-3-(2,5-DIFLUOROPHENYL)-6((1-METHYL-1H-1,2,4-TRIAZOL-5-YL)METHOXY)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE | CONCERT PHARMACEUTICALS, INC. (US) | 2013-11-14 | — | — | WO | disclosed |