Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 18/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15530845 | 0.82 | NAMPT (0.66) | NAMPTPOLBCYP2C9 | |
| SCHEMBL163456 | 0.82 | NAMPT (0.75) | NAMPTCYP2C9 | |
| SCHEMBL12503625 | 0.82 | NAMPT (0.75) | NAMPTCYP2C9 | |
| SCHEMBL163455 | 0.82 | NAMPT (0.75) | NAMPTCYP2C9 | |
| SCHEMBL15530163 | 0.81 | NAMPT (0.58) | NAMPTPOLBCYP2C9 | |
| SCHEMBL164793 | 0.80 | NAMPT (0.80) | NAMPTCYP2C9 | |
| SCHEMBL15530664 | 0.79 | NAMPT (0.72) | NAMPTCYP2C9 | |
| SCHEMBL15530551 | 0.77 | NAMPT (0.74) | NAMPT | |
| SCHEMBL10290830 | 0.77 | POLB (0.71) | NAMPTPOLBCYP2C9 | |
| SCHEMBL15531121 | 0.75 | NAMPT (0.70) | NAMPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013170191-A1 | METHODS OF USING ANTAGONISTS OF NAD BIOSYNTHESIS FROM NICOTINAMIDE | GENENTECH, INC. (US) | 2013-11-14 | — | — | WO | disclosed |