Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 20/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15378359 | 1.00 | GLS (0.44) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15379555 | 0.95 | GLS (0.40) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15379700 | 0.91 | GLS (0.44) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15380319 | 0.89 | USP30 (0.46) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15379867 | 0.89 | GLS (0.44) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15380320 | 0.89 | USP30 (0.46) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15379291 | 0.88 | GLS (0.48) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15531078 | 0.88 | GLS (0.48) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15379521 | 0.87 | GLS (0.44) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL15380089 | 0.86 | GLS (0.40) | GLSSLC6A2TACR1OPRM1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2847181-A1 | PYRIDAZINE AND PYRIDINE DERIVATIVES AS NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-03-18 | — | — | EP | claimed |
| WO-2013170115-A1 | PYRIDAZINE AND PYRIDINE DERIVATIVES AS NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |
| EP-2847181-A1 | PYRIDAZINE AND PYRIDINE DERIVATIVES AS NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013170115-A1 | PYRIDAZINE AND PYRIDINE DERIVATIVES AS NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |