Sugi Predict

Sugi Predict / Targets / GLS

GLS

Glutaminase kidney isoform, mitochondrial · O94925 · GLS on Sugi Atlas →

40,275 patent compounds predicted against GLS, 21,506 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL851272 SCHEMBL851272 0.55 9/20
SCHEMBL982339 SCHEMBL982339 0.50 9/20
SCHEMBL282603 SCHEMBL282603 0.52 8/20
SCHEMBL1029323 SCHEMBL1029323 0.52 8/20
SCHEMBL758724 SCHEMBL758724 0.49 8/20
SCHEMBL1030010 SCHEMBL1030010 0.46 8/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL980503) 0.60 6/20
SCHEMBL694491 SCHEMBL694491 0.56 6/20
SCHEMBL24068 SCHEMBL24068 0.51 6/20
SCHEMBL966286 SCHEMBL966286 0.50 6/20
SCHEMBL690748 SCHEMBL690748 0.45 6/20
SCHEMBL1077039 SCHEMBL1077039 0.45 6/20
SCHEMBL758472 SCHEMBL758472 0.44 6/20
SCHEMBL894206 SCHEMBL894206 0.55 5/20
SCHEMBL184953 SCHEMBL184953 0.54 5/20
SCHEMBL435901 SCHEMBL435901 0.54 5/20
SCHEMBL233399 SCHEMBL233399 0.50 5/20
SCHEMBL507223 SCHEMBL507223 0.49 5/20
SCHEMBL254558 SCHEMBL254558 0.46 5/20
SCHEMBL209423 SCHEMBL209423 0.62 4/20

Clinical trials — most relevant to GLS by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
How Does the Diabetes Drug, Pioglitazone, Reduce Protein Loss in the Urine? PHASE4UNKNOWN
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression PHASE2/PHASE3NOT_YET_RECRUITING
Cysteine Supplementation in Critically Ill Neonates PHASE2/PHASE3UNKNOWN
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
The Impact of Metformin Administration on the Clinical Outcome of Stage IV Colon Cancer PHASE3COMPLETED
Trial of Oral Glutamine on Mitochondrial Function in CKD PHASE2COMPLETED
Prevent Cardiac Surgery Associated AKI Trial PHASE2RECRUITING
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension PHASE2NOT_YET_RECRUITING
Bempedoic Acid Therapy for Polycystic Kidney Disease PHASE2NOT_YET_RECRUITING
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
The KHENERGY Study PHASE2COMPLETED
Anaplerotic Therapy in Propionic Acidemia PHASE1COMPLETED
Oral Glutamine in Cardiopulmonary Bypass nanCOMPLETED
Hydroxyl Free Radical Associated Effects of SGLT-2 Inhibitors in Type 2 Diabetes nanCOMPLETED
Relation of White Blood Cell Function to Diabetes nanCOMPLETED
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Effect of Nutritional Supplementation and Pulmonary Rehabilitation on the Clinical Status of HF and COPD nanUNKNOWN
Assessment of Protein Modification in Chronic Kidney Disease - Selected Clinical and Biochemical Aspects nanCOMPLETED
Pathophysiology of Uric Acid Nephrolithiasis nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation nanRECRUITING
Outcome of Use of a Novel Modulator of Oxidative Phosphorylation on Kidney Function in Patients With Progressive Chronic Kidney Disease nanCOMPLETED
Effect of an Polyphenolic Beverage in Healthy Volunteers nanACTIVE_NOT_RECRUITING
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD nanCOMPLETED
Plasma Biomarkers of Muscle Metabolism During Exercise to the Assessment of Insulin Resistance in CKD Dialysis Patients nanRECRUITING
Mitochondrial Assessment in Critical Ill Patients in Intensive Care nanNOT_YET_RECRUITING
In and ex Vivo Mitochondrial Function of the Heart nanCOMPLETED
Predicts Mortality by AST/ALT Ration in Patients with Sepsis and Septic Shock During ICU Admissin nanNOT_YET_RECRUITING
Thyroid Hormones in CKD nanNOT_YET_RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GLS binder may also engage these)

ProteinNameSimilarity
D3Z7P3 — 1.000 D3Z7P3 →
P13264 — 1.000 P13264 →
Q28D01 — 0.957 Q28D01 →
WDR26 WD repeat-containing protein 26 0.957 landscape →
A0A2R8QFQ6 — 0.956 A0A2R8QFQ6 →
Q8C6G8 — 0.954 Q8C6G8 →
CHKA Choline kinase alpha 0.952 landscape →
P20595 — 0.952 P20595 →
Q3MHJ2 — 0.952 Q3MHJ2 →
CDC16 Cell division cycle protein 16 homolog 0.951 landscape →
Q4ZHR9 — 0.951 Q4ZHR9 →
ABHD12 Lysophosphatidylserine lipase ABHD12 0.950 landscape →
Q4R766 — 0.950 Q4R766 →
P16068 — 0.950 P16068 →
Q8BWB6 — 0.949 Q8BWB6 →
Q8CJ19 — 0.949 Q8CJ19 →
Q32NS4 — 0.949 Q32NS4 →
G3MWR8 — 0.949 G3MWR8 →
Q7Z6J6 — 0.948 Q7Z6J6 →
Q7RTP6 — 0.948 Q7RTP6 →
Q8R349 — 0.947 Q8R349 →
KCNT1 Potassium channel subfamily T member 1 0.947 landscape →
O54865 — 0.947 O54865 →
Q9Y297 — 0.947 Q9Y297 →
Q4W5Z4 — 0.947 Q4W5Z4 →
Q5ZIN0 — 0.946 Q5ZIN0 →
Q5NVN7 — 0.946 Q5NVN7 →
A0A2R8RWN9 — 0.946 A0A2R8RWN9 →
Q6PFJ9 — 0.946 Q6PFJ9 →
A6QLE6 — 0.946 A6QLE6 →