Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25753188 | 1.00 | EPHX2 (0.45) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL2084363 | 0.98 | EPHX2 (0.43) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL16682526 | 0.88 | EPHX2 (0.44) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL482480 | 0.81 | ALDH1A1 (0.41) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL15532601 | 0.80 | GRIN2D (0.39) | MEN1KMT2AALDH1A1HTTNPSR1 | |
| SCHEMBL15532220 | 0.80 | GRIN2D (0.39) | MEN1KMT2AALDH1A1HTTNPSR1 | |
| SCHEMBL12687856 | 0.80 | MEN1 (0.44) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL21997787 | 0.80 | MEN1 (0.44) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL15532888 | 0.80 | MEN1 (0.44) | EPHX2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL15533296 | 0.80 | GRIN2D (0.39) | MEN1KMT2AALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846784-A1 | COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME | Yale University (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013170147-A1 | COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME | YALE UNIVERSITY (US) | 2013-11-14 | — | — | WO | disclosed |