Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011966 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2HIF1ATAAR1ALDH1A1HTR1A | |
| SCHEMBL17129221 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1SYKNPC1RAB9A | |
| SCHEMBL30257063 | 0.87 | AAK1 (0.47) | SMN1; SMN2SYKCTSSCTSKNPC1 | |
| SCHEMBL16363856 | 0.87 | CTSS (0.45) | SMN1; SMN2SYKCTSSCTSKNPC1 | |
| SCHEMBL29861722 | 0.87 | NPC1 (0.43) | SMN1; SMN2SYKNPC1RAB9ALMNA | |
| SCHEMBL24298740 | 0.87 | NPC1 (0.43) | SMN1; SMN2SYKCTSSCTSKNPC1 | |
| SCHEMBL2434610 | 0.87 | CTSS (0.45) | SMN1; SMN2SYKCTSSCTSKNPC1 | |
| SCHEMBL17373694 | 0.87 | AAK1 (0.47) | SMN1; SMN2SYKCTSSCTSKNPC1 | |
| SCHEMBL3657534 | 0.87 | GAA (0.48) | SMN1; SMN2ALDH1A1SYKNPC1RAB9A | |
| SCHEMBL29861985 | 0.87 | NPC1 (0.43) | SMN1; SMN2SYKNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |