Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.68 |
| ▸ | CLK1 | P49759 | 11/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.68 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.68 |
| ▸ | CLK2 | P49760 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CLK3 | P49761 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534551 | 0.83 | CLK4 (0.74) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL15534426 | 0.82 | TRPV1 (0.51) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL15534293 | 0.81 | SYK (0.49) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL15534386 | 0.81 | DYRK1A (0.68) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL15533939 | 0.81 | CLK1 (1.00) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL27115516 | 0.80 | SYK (0.48) | SYK | |
| SCHEMBL15534400 | 0.79 | CLK1 (0.65) | CLK4CLK1DYRK1ADYRK1BCLK2 | |
| SCHEMBL15533965 | 0.77 | SYK (0.51) | CLK4DYRK1AKDM4ENPC1RAB9A | |
| SCHEMBL27115517 | 0.76 | SYK (0.47) | NPC1RAB9ACDK2MEN1KMT2A | |
| SCHEMBL15533263 | 0.76 | CLK1 (0.64) | CLK4CLK1DYRK1ADYRK1BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |