Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.49 |
| ▸ | IDH2 | P48735 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27115516 | 0.89 | SYK (0.48) | SYKIDH2PLK1 | |
| SCHEMBL15534057 | 0.82 | CLK1 (0.47) | SYKIDH2KDM4EMEN1ALDH1A1 | |
| SCHEMBL15533965 | 0.82 | SYK (0.51) | SYKKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL15533935 | 0.81 | CLK4 (0.68) | SYKKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27115517 | 0.81 | SYK (0.47) | SYKIDH2MEN1MAPTKMT2A | |
| SCHEMBL15534348 | 0.80 | MEN1 (0.46) | SYKKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL15533252 | 0.80 | DKK1 (0.47) | SYKCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL15533886 | 0.80 | CLK1 (0.67) | SYKKDM4ECLK1CLK2DYRK1A | |
| SCHEMBL15534101 | 0.80 | TRPV1 (0.47) | KDM4EMEN1POLBMAPTKMT2A | |
| SCHEMBL15533101 | 0.79 | CCNB2 (0.55) | KDM4EMEN1ALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |