Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373904 | 0.83 | BACE1 (0.51) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL20159003 | 0.82 | MAPT (0.59) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL5366413 | 0.82 | BACE1 (0.49) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL2386747 | 0.81 | GPR119 (0.59) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL24124829 | 0.80 | MAPT (0.56) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL5366552 | 0.80 | TP53 (0.49) | ALDH1A1LMNAMAPTGPR119BACE1 | |
| SCHEMBL14992693 | 0.80 | MAPT (0.56) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL5256454 | 0.80 | MAPT (0.56) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL21995916 | 0.80 | TP53 (0.49) | PDK2ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL30992952 | 0.80 | MAPT (0.51) | PDK2ALDH1A1LMNAMAPTGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177253-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |