Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 19/20 | 0.38 |
| ▸ | PIM1 | P11309 | 16/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 16/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15872955 | 0.85 | BRS3 (0.35) | BRS3 | |
| SCHEMBL15534692 | 0.85 | BRS3 (0.35) | BRS3 | |
| SCHEMBL15534694 | 0.85 | BRS3 (0.35) | BRS3 | |
| SCHEMBL18430046 | 0.85 | BRS3 (0.35) | BRS3 | |
| SCHEMBL19371100 | 0.85 | BRS3 (0.35) | BRS3 | |
| SCHEMBL17286146 | 0.84 | PIM2 (0.45) | PIM2PIM1PIM3 | |
| SCHEMBL17286160 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3 | |
| SCHEMBL15588962 | 0.81 | PIM2 (0.47) | PIM2PIM1PIM3 | |
| SCHEMBL15887134 | 0.79 | PIM1 (0.39) | PIM2PIM1PIM3 | |
| SCHEMBL17282381 | 0.79 | PIM2 (0.49) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861585-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013175388-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |