Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | PRKDC | P78527 | 1/20 | 0.60 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.60 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.60 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 9/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 8/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL594269 | 0.92 | PIK3CA (0.72) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL8232831 | 0.87 | PIK3CA (0.64) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6942914 | 0.84 | PIK3CA (0.65) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| Bicarbonate SCHEMBL1552914 | 0.82 | PIK3CA (0.68) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6942524 | 0.82 | PIK3CA (0.81) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL13614701 | 0.82 | PIK3CA (0.81) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6942234 | 0.81 | RAF1 (0.77) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL6942969 | 0.81 | MTOR (0.70) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| Bicarbonate SCHEMBL1552842 | 0.81 | PIK3CA (0.87) | PIK3CAPIK3CBMTORPIK3CGPRKDC | |
| SCHEMBL8400352 | 0.80 | FGFR1 (0.66) | PIK3CAPIK3CBMTORPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951724-B1 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARM INC (US) | 2011-04-27 | — | — | EP | claimed |