Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.75 |
| ▸ | PDE4A | P27815 | 12/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.75 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552878 | 0.82 | PDE4D (0.86) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8571281 | 0.80 | PDE4A (0.46) | PDE4BPDE4DPDE4APDE4CPBK | |
| SCHEMBL1553041 | 0.78 | PDE4D (0.85) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1553706 | 0.69 | PDE4D (0.71) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1552882 | 0.69 | PDE4D (0.85) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1553543 | 0.69 | PDE4D (1.00) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1553562 | 0.69 | PDE4D (0.69) | PDE4BPDE4DPDE4APDE4CPBK | |
| SCHEMBL7474591 | 0.67 | PDE4D (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1553990 | 0.67 | PDE4D (0.68) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7425565 | 0.67 | PDE4D (0.59) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934307-B1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | AVENTIS PHARMA LTD (GB) | 2011-04-27 | — | — | EP | claimed |
| EP-0934307-A1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | RHONE-POULENC RORER LIMITED (GB) | 1999-08-11 | — | — | EP | claimed |
| WO-1997048697-A1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | RHONE-POULENC RORER LIMITED (GB) | 1997-12-24 | — | — | WO | claimed |