Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075289 | 0.82 | ALDH1A1 (0.32) | SCN9AALDH1A1TDP1 | |
| SCHEMBL17428576 | 0.82 | ALDH1A1 (0.32) | SCN9AALDH1A1TDP1 | |
| SCHEMBL28233959 | 0.78 | SCN9A (0.33) | SCN9AALDH1A1TDP1 | |
| SCHEMBL30976057 | 0.77 | EPHX1 (0.37) | EPHX1 | |
| SCHEMBL17003738 | 0.77 | KDM4E (0.38) | EPHX1ALDH1A1TDP1 | |
| SCHEMBL17339729 | 0.75 | KDM4E (0.51) | EPHX1ALDH1A1TDP1 | |
| SCHEMBL19483163 | 0.75 | ESR2 (0.36) | ALDH1A1TDP1 | |
| SCHEMBL14047871 | 0.75 | ESR2 (0.36) | ALDH1A1TDP1 | |
| SCHEMBL16449045 | 0.74 | ALDH1A1 (0.36) | ALDH1A1TDP1 | |
| SCHEMBL26196760 | 0.74 | EPHX1 (0.42) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104718188-B | The benzamides of N- substitutions and its purposes in treating pain | 基因泰克公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-104718188-A | N-substituted benzamides and their use in the treatment of pain | GENENTECH INC | 2015-06-17 | — | — | CN | disclosed |
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |