Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535994 | 0.82 | GNRHR (0.38) | NR1H2NR1H3RORCGNRHRP2RY14 | |
| SCHEMBL3848575 | 0.82 | EGLN3 (0.54) | RORCESR1MAPK13MAPK12MAPK11 | |
| SCHEMBL3854878 | 0.81 | ALDH1A1 (0.46) | NR1H2NR1H3NR1I2NR3C1RORC | |
| SCHEMBL3853220 | 0.74 | EGLN3 (0.49) | RORCMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3263973 | 0.74 | GNRHR (0.37) | RORCGNRHREPHX2KDM4EALDH1A1 | |
| SCHEMBL3847891 | 0.73 | ALDH1A1 (0.41) | RORCP2RY14KDM4EALDH1A1 | |
| SCHEMBL3847819 | 0.69 | ALDH1A1 (0.38) | RORCP2RY14KDM4EALDH1A1 | |
| SCHEMBL15537015 | 0.69 | GAA (0.43) | MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL3854160 | 0.68 | EGLN3 (0.45) | RORCMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3849543 | 0.67 | ALDH1A1 (0.47) | NR1H2NR1H3MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177478-A2 | TREATMENT METHOD | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2013-11-28 | — | — | WO | disclosed |