Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20211615 | 1.00 | KDM4E (1.00) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL15537736 | 1.00 | KDM4E (1.00) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL8651078 | 0.73 | GAA (0.57) | KDM4EMEN1GAAKMT2AMAPT | |
| SCHEMBL22924546 | 0.72 | KDM4E (0.55) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL7000985 | 0.70 | KDM4E (0.54) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL7001705 | 0.70 | PARP1 (0.64) | KDM4EMEN1GAAKMT2AMAOA | |
| SCHEMBL24377996 | 0.67 | KMT2A (0.50) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL22902405 | 0.67 | ALOX5 (0.63) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL8470138 | 0.67 | KDM4E (0.52) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL29242170 | 0.65 | KDM4E (0.59) | KDM4EMEN1GAAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150337018-A1 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2015-11-26 | — | — | US | claimed |
| EP-2897632-A2 | COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS | Universidad Andres Bello (CL) | 2015-07-29 | — | — | EP | claimed |
| WO-2013179264-A2 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2013-12-05 | — | — | WO | claimed |
| US-9879058-B2 | Use of compounds that selectively modulate astrocytic release of substances through hemichannels of connexins and pannexins, without influencing gap junctions, for the treatment of psychiatric disorders | UNIVERSIDAD ANDRES BELLO (CL) | 2018-01-30 | — | — | US | disclosed |
| US-20150337018-A1 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2015-11-26 | — | — | US | disclosed |
| US-9101573-B2 | Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| EP-2897632-A2 | COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS | Universidad Andres Bello (CL) | 2015-07-29 | — | — | EP | disclosed |
| WO-2013179264-A2 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2013-12-05 | — | — | WO | disclosed |