Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.61 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538363 | 0.94 | BRD4 (0.59) | BRD4FFAR4PTGS2 | |
| SCHEMBL28012175 | 0.91 | BRD4 (0.64) | BRD4FFAR4PTGS2 | |
| SCHEMBL20135835 | 0.91 | BRD4 (0.58) | BRD4FFAR4 | |
| SCHEMBL15539499 | 0.89 | BRD4 (0.62) | BRD4FFAR4PTGS2TP53 | |
| SCHEMBL28012062 | 0.89 | BRD4 (0.64) | BRD4FFAR4PTGS2 | |
| SCHEMBL15538774 | 0.89 | BRD4 (0.56) | BRD4FFAR4PTGS2TP53MDM2 | |
| SCHEMBL15540441 | 0.88 | BRD4 (0.58) | BRD4FFAR4 | |
| SCHEMBL28012051 | 0.87 | BRD4 (0.65) | BRD4FFAR4PTGS2 | |
| SCHEMBL15559351 | 0.86 | BRD4 (0.60) | BRD4FFAR4PTGS2 | |
| SCHEMBL15539387 | 0.85 | BRD4 (0.57) | BRD4FFAR4PTGS2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | claimed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | claimed |
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | disclosed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | disclosed |