Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15540331 | 1.00 | TDP1 (0.39) | TDP1ALDH1A1CYP3A4TSHRGFER | |
| SCHEMBL15540864 | 1.00 | TDP1 (0.39) | TDP1ALDH1A1CYP3A4TSHRGFER | |
| SCHEMBL6076750 | 0.80 | KDM4E (0.49) | ALDH1A1CYP3A4TSHRLOXL2MAOB | |
| SCHEMBL16587900 | 0.80 | IDO1 (0.43) | ALDH1A1MAPK1IDO1 | |
| SCHEMBL1444575 | 0.80 | KDM4E (0.49) | ALDH1A1CYP3A4TSHRLOXL2MAOB | |
| SCHEMBL5341514 | 0.80 | IDO1 (0.42) | ALDH1A1CYP3A4TSHRMAOBTP53 | |
| SCHEMBL9278957 | 0.79 | MAOB (0.46) | ALDH1A1TSHRMAPK1MAOBTP53 | |
| SCHEMBL7966000 | 0.79 | MAOB (0.46) | ALDH1A1TSHRMAPK1MAOBTP53 | |
| Hydrochloric Acid SCHEMBL1782945 | 0.78 | KDM4E (0.38) | TDP1ALDH1A1CYP3A4TSHRTP53 | |
| SCHEMBL7784327 | 0.77 | CA2 (0.51) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013188856-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | GILEAD CONNECTICUT, INC. (US) | 2013-12-19 | — | — | WO | disclosed |