SCHEMBL15540780

SCHEMBL15540780

COc1ccc2c(c1)CCC(CNOC(C)=O)C2c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.65
MTNR1A P48039 5/20 0.49
MTNR1B P49286 4/20 0.49
GRIN2B Q13224 4/20 0.46
GRIN1 Q05586 1/20 0.46
PPARD Q03181 2/20 0.44
TRPV1 Q8NER1 2/20 0.42
NPY5R Q15761 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
NQO2 P16083 1/20 0.41
TAS2R14 Q9NYV8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7711882 0.85 SLC6A9 (0.67) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7703435 0.85 SLC6A9 (0.67) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
SCHEMBL31757157 0.84 SLC6A9 (0.69) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7703438 0.84 SLC6A9 (0.60) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
SCHEMBL7706108 0.84 SLC6A9 (0.69) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7700473 0.82 SLC6A9 (0.63) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7700471 0.82 SLC6A9 (0.63) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7700472 0.82 SLC6A9 (0.63) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7705416 0.82 SLC6A9 (0.66) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1
Hydrochloric Acid SCHEMBL7705418 0.82 SLC6A9 (0.63) SLC6A9MTNR1AMTNR1BGRIN2BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013188465-A2 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING DRUG ADDICTION AND PREVENTING A DRUG RELAPSE ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY (US) 2013-12-19 WO disclosed