Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10016064 | 0.84 | PREP (0.39) | HDAC6PREPFAPPOLBL3MBTL1 | |
| SCHEMBL1650978 | 0.79 | EGLN1 (0.44) | HDAC6PREPFAPPOLBL3MBTL1 | |
| SCHEMBL684235 | 0.79 | PREP (0.39) | HDAC6PREPFAPPOLBL3MBTL1 | |
| SCHEMBL24489837 | 0.78 | POLB (0.38) | HDAC6PREPFAPPOLBL3MBTL1 | |
| SCHEMBL607515 | 0.78 | — | — | |
| SCHEMBL12388730 | 0.77 | TET2 (0.54) | HDAC6PREPFAPPOLBCA1 | |
| SCHEMBL5544499 | 0.77 | MAOA (0.38) | HDAC6PREPFAPPOLBL3MBTL1 | |
| SCHEMBL8787301 | 0.77 | EGLN1 (0.43) | HDAC6PREPFAPPOLBL3MBTL1 | |
| SCHEMBL15699545 | 0.77 | PREP (0.38) | HDAC6PREPFAPPOLBL3MBTL1 | |
| Acetic Acid SCHEMBL7511053 | 0.77 | POLB (0.40) | HDAC6PREPFAPPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861565-A2 | SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY | The Regents of The University of California (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013188750-A2 | SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-12-19 | — | — | WO | disclosed |