Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401165 | 0.76 | PIM1 (0.67) | PIM1PIM3PIM2 | |
| SCHEMBL15543866 | 0.74 | PIM1 (0.44) | PIM1PIM3PIM2MAPTNPC1 | |
| SCHEMBL15543220 | 0.72 | MAPT (0.35) | PIM1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17441671 | 0.67 | MAPT (0.45) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL15544513 | 0.67 | MEN1 (0.41) | PIM1PIM3PIM2MAPTNPC1 | |
| SCHEMBL15543788 | 0.67 | MAPT (0.36) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL15543095 | 0.60 | PIM1 (0.39) | PIM1PIM3PIM2 | |
| SCHEMBL15543181 | 0.57 | PIM1 (0.41) | PIM1PIM3PIM2AR | |
| SCHEMBL13822164 | 0.56 | ASIC3 (0.47) | PIM1MAPTNPC1SMN1; SMN2KDM4E | |
| SCHEMBL16159178 | 0.56 | PIM1 (0.43) | PIM1MAPTCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867232-A1 | 5-AZAINDAZOLE COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2015-05-06 | — | — | EP | disclosed |
| WO-2014001377-A1 | 5-AZAINDAZOLE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-03 | — | — | WO | disclosed |