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ASIC3

Acid-sensing ion channel 3 · Q9UHC3 · ASIC3 on Sugi Atlas →

12,419 patent compounds predicted against ASIC3, 7,583 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1010614 SCHEMBL1010614 0.61 7/20
SCHEMBL587208 SCHEMBL587208 0.60 7/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL588201) 0.58 7/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL587643) 0.56 7/20
SCHEMBL1199539 SCHEMBL1199539 0.60 6/20
SCHEMBL1011047 SCHEMBL1011047 0.58 6/20
SCHEMBL1010747 SCHEMBL1010747 0.56 6/20
SCHEMBL1020108 SCHEMBL1020108 0.55 6/20
SCHEMBL329770 SCHEMBL329770 0.69 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1000104) 0.68 4/20
SCHEMBL330372 SCHEMBL330372 0.60 4/20
SCHEMBL1012895 SCHEMBL1012895 0.59 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1000880) 0.58 4/20
SCHEMBL1431297 SCHEMBL1431297 0.55 4/20
SCHEMBL1009138 SCHEMBL1009138 0.54 4/20
SCHEMBL693160 SCHEMBL693160 0.49 4/20
SCHEMBL717466 SCHEMBL717466 0.44 4/20
SCHEMBL537786 SCHEMBL537786 0.37 4/20
SCHEMBL558453 SCHEMBL558453 1.00 3/20
SCHEMBL314105 SCHEMBL314105 0.67 3/20

Clinical trials — most relevant to ASIC3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve PHASE2UNKNOWN
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
Evaluating Possible Improvement in Tinnitus Severity After 28 Days Dosing of the Study Drug AUT00063 Compared to Placebo PHASE2COMPLETED
Evaluating Possible Improvement in Speech and Hearing Tests After 28 Days of Dosing of the Study Drug AUT00063 Compared to Placebo (QuicKfire) PHASE2COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn PHASE1COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Precision Medicine for Sng/Pain Control nanCOMPLETED
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Precision Medicine for Nociception, Sngception and Proprioception. nanRECRUITING
The Natural History of TRPV4 Neuropathy nanRECRUITING
Detection of Clinically Significant Prostate Cancer Using a Urinary Multimarker Sensor nanUNKNOWN
Na+ Channel mRNA Regulation in Heart Failure nanCOMPLETED
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13) nanNOT_YET_RECRUITING
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Painful Channelopathies Study nanUNKNOWN
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in Health nanCOMPLETED
Cardiovascular Effects of Empagliflozine nanUNKNOWN
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a ASIC3 binder may also engage these)

ProteinNameSimilarity
O35240 — 1.000 O35240 →
Q6X1Y6 — 1.000 Q6X1Y6 →
O97742 — 0.982 O97742 →
Q708S3 — 0.979 Q708S3 →
H2QAR5 — 0.975 H2QAR5 →
Q28738 — 0.974 Q28738 →
Q95165 — 0.974 Q95165 →
O62816 — 0.973 O62816 →
Q9WU38 — 0.973 Q9WU38 →
A5D7U4 — 0.972 A5D7U4 →
Q9TT93 — 0.972 Q9TT93 →
P37090 — 0.971 P37090 →
SCNN1B Epithelial sodium channel subunit beta 0.971 landscape →
Q8BNJ2 — 0.969 Q8BNJ2 →
Q9WU39 — 0.969 Q9WU39 →
SCNN1G Epithelial sodium channel subunit gamma 0.969 landscape →
Q708S8 — 0.968 Q708S8 →
F1MJW3 — 0.968 F1MJW3 →
Q8IZY2 — 0.967 Q8IZY2 →
Q8JGM4 — 0.967 Q8JGM4 →
ADAMTS7 A disintegrin and metalloproteinase with thrombospondin motifs 7 0.967 landscape →
Q8WXS8 — 0.966 Q8WXS8 →
Q69ZK9 — 0.965 Q69ZK9 →
Q9H324 — 0.965 Q9H324 →
Q8TE58 — 0.965 Q8TE58 →
H1AFJ5 — 0.965 H1AFJ5 →
Q62888 — 0.965 Q62888 →
P17491 — 0.964 P17491 →
Q8BYM5 — 0.964 Q8BYM5 →
Q5RFQ8 — 0.964 Q5RFQ8 →