Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15581938 | 0.93 | FASN (0.49) | FASNKDM4EOPRM1SIGMAR1KCNH2 | |
| SCHEMBL15543122 | 0.91 | FASN (0.49) | FASNOPRM1SIGMAR1NPY5R | |
| SCHEMBL15544285 | 0.89 | FASN (0.65) | FASNOPRM1SIGMAR1ALDH1A1 | |
| SCHEMBL15544087 | 0.88 | FASN (0.48) | FASNKDM4EOPRM1SIGMAR1KCNH2 | |
| SCHEMBL15543780 | 0.88 | FASN (0.51) | FASNOPRM1SIGMAR1ALDH1A1NPY5R | |
| SCHEMBL15543510 | 0.87 | FASN (0.60) | FASNOPRM1SIGMAR1ALDH1A1 | |
| SCHEMBL15555329 | 0.87 | FASN (0.44) | FASNKDM4EOPRM1SIGMAR1KCNH2 | |
| Trifluoroacetic Acid SCHEMBL15544084 | 0.87 | FASN (0.45) | FASNOPRM1SIGMAR1KCNH2 | |
| SCHEMBL15559030 | 0.86 | FASN (0.45) | FASNOPRM1KCNH2ALDH1A1CXCR3 | |
| SCHEMBL15543505 | 0.85 | FASN (0.48) | FASNOPRM1SIGMAR1KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |