Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 11/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543510 | 0.97 | FASN (0.60) | FASNOPRM1SIGMAR1ALDH1A1MAPK1 | |
| SCHEMBL15581938 | 0.89 | FASN (0.49) | FASNOPRM1SIGMAR1ALDH1A1CHRM1 | |
| SCHEMBL15543306 | 0.89 | FASN (0.49) | FASNOPRM1SIGMAR1ALDH1A1 | |
| SCHEMBL15544827 | 0.87 | FASN (0.49) | FASNOPRM1SIGMAR1ALDH1A1MAPK1 | |
| SCHEMBL15543784 | 0.87 | FASN (0.50) | FASNOPRM1SIGMAR1ALDH1A1MAPK1 | |
| SCHEMBL15544087 | 0.84 | FASN (0.48) | FASNOPRM1SIGMAR1ALDH1A1CHRM1 | |
| SCHEMBL14842076 | 0.84 | FASN (0.65) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15543780 | 0.84 | FASN (0.51) | FASNOPRM1SIGMAR1ALDH1A1MAPK1 | |
| SCHEMBL15543468 | 0.84 | FASN (0.57) | FASNOPRM1SIGMAR1CHRM1 | |
| SCHEMBL15544977 | 0.84 | FASN (0.51) | FASNOPRM1SIGMAR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |