Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 8/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15559477 | 0.80 | FASN (0.38) | FASNGSK3BCHRM1HTR2AHTR2C | |
| SCHEMBL15543968 | 0.79 | CHRM1 (0.40) | FASNGSK3BCHRM1 | |
| SCHEMBL15543695 | 0.78 | FASN (0.39) | FASNGSK3BCHRM1KDM1ADDB1 | |
| SCHEMBL15544455 | 0.76 | FASN (0.34) | FASNCHRM1 | |
| SCHEMBL15544262 | 0.76 | FASN (0.35) | FASNGSK3BKDM1ADDB1CRBN | |
| SCHEMBL15543841 | 0.75 | FASN (0.38) | FASN | |
| SCHEMBL15556001 | 0.74 | CTSK (0.31) | — | |
| SCHEMBL15543763 | 0.73 | FASN (0.39) | FASNCHRM1 | |
| SCHEMBL15544558 | 0.73 | FASN (0.38) | FASNGSK3BKDM1ADDB1CRBN | |
| SCHEMBL15544962 | 0.71 | FASN (0.38) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |