Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.48 |
| ▸ | CTSS | P25774 | 4/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543310 | 0.91 | FASN (0.48) | FASNCTSSLTA4HOPRM1SIGMAR1 | |
| SCHEMBL15543524 | 0.91 | FASN (0.49) | FASNOPRM1SIGMAR1 | |
| SCHEMBL15544250 | 0.90 | FASN (0.47) | FASNGRIN2BGRIN1LTA4H | |
| SCHEMBL15543199 | 0.89 | FASN (0.47) | FASNLTA4HOPRM1SIGMAR1 | |
| SCHEMBL15543586 | 0.88 | FASN (0.63) | FASNCTSSGRIN2BGRIN1EGLN1 | |
| SCHEMBL15543780 | 0.83 | FASN (0.51) | FASNOPRM1SIGMAR1NPY5R | |
| SCHEMBL14842023 | 0.82 | FASN (0.46) | FASNGRIN2BGRIN1NPY5R | |
| SCHEMBL15543588 | 0.81 | FASN (0.48) | FASNLTA4HOPRM1SIGMAR1 | |
| SCHEMBL15544244 | 0.81 | FASN (0.49) | FASNOPRM1SIGMAR1NPY5R | |
| SCHEMBL15543895 | 0.81 | FASN (0.49) | FASNLTA4HOPRM1SIGMAR1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |