Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15555329 | 0.90 | FASN (0.44) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15555919 | 0.90 | FASN (0.46) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15581799 | 0.88 | FASN (0.48) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15557104 | 0.86 | FASN (0.41) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15556670 | 0.84 | FASN (0.44) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15543896 | 0.84 | FASN (0.41) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15556185 | 0.83 | FASN (0.43) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4560948 | 0.83 | FASN (0.55) | FASNOPRM1KDM4EALDH1A1KCNH2 | |
| SCHEMBL15543403 | 0.82 | FASN (0.47) | FASNOPRM1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL15582392 | 0.82 | FASN (0.38) | FASNOPRM1SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |