Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.34 |
| ▸ | MLNR | O43193 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15544224 | 0.91 | FASN (0.47) | FASNPDE4AJAK2JAK1JAK3 | |
| SCHEMBL15543589 | 0.89 | FASN (0.45) | FASNPDE4ABCHEMAPK1ALDH1A1 | |
| SCHEMBL14842076 | 0.84 | FASN (0.65) | FASNKDM1A | |
| SCHEMBL14842084 | 0.84 | FASN (0.43) | FASNPDE4APDE4CPDE4D | |
| SCHEMBL15543468 | 0.83 | FASN (0.57) | FASNKDM1A | |
| SCHEMBL14720265 | 0.82 | FASN (0.44) | FASNPDE4AKDM1APDE4CPDE4D | |
| SCHEMBL15582390 | 0.81 | FASN (0.60) | FASNJAK2SSTR5KDM1A | |
| SCHEMBL15544405 | 0.81 | FASN (0.49) | FASNJAK2JAK1TYK2JAK3 | |
| SCHEMBL15581938 | 0.81 | FASN (0.49) | FASNALDH1A1SSTR5 | |
| SCHEMBL4542364 | 0.80 | FASN (0.69) | FASNPDE4AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |