Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 6/20 | 0.49 |
| ▸ | MLNR | O43193 | 3/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842076 | 0.86 | FASN (0.65) | FASNOPRM1CHRM1SIGMAR1 | |
| SCHEMBL15543468 | 0.86 | FASN (0.57) | FASNOPRM1CHRM1SIGMAR1 | |
| SCHEMBL15544977 | 0.84 | FASN (0.51) | FASNACVR1OPRM1CHRM1SIGMAR1 | |
| SCHEMBL4542733 | 0.84 | FASN (0.60) | FASNACVR1ERN1 | |
| SCHEMBL15544087 | 0.82 | FASN (0.48) | FASNJAK2TYK2OPRM1OPRK1 | |
| SCHEMBL15582390 | 0.81 | FASN (0.60) | FASNJAK2OPRM1SIGMAR1 | |
| SCHEMBL14720162 | 0.81 | FASN (0.46) | FASNACVR1ERN1JAK1JAK3 | |
| SCHEMBL15544476 | 0.81 | FASN (0.47) | FASNMLNRJAK2JAK1TYK2 | |
| SCHEMBL15544497 | 0.80 | FASN (0.42) | FASNJAK2TYK2OPRM1OPRK1 | |
| SCHEMBL15581938 | 0.79 | FASN (0.49) | FASNOPRM1OPRK1CHRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |