Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15544876 | 1.00 | ATM (0.41) | ATMHTTPKMALDH1A1MAPT | |
| SCHEMBL16680964 | 0.93 | ATM (0.45) | ATMHTTPKMALDH1A1MAPT | |
| SCHEMBL16680963 | 0.93 | ATM (0.45) | ATMHTTPKMALDH1A1MAPT | |
| SCHEMBL181084 | 0.81 | HTT (0.49) | HTTPKMMAPTKMT2AMEN1 | |
| SCHEMBL29764890 | 0.81 | HTT (0.49) | HTTPKMMAPTKMT2AMEN1 | |
| SCHEMBL22557892 | 0.75 | PKM (0.47) | HTTPKMALDH1A1MAPTKMT2A | |
| SCHEMBL15544893 | 0.73 | ADORA2A (0.42) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL15545354 | 0.73 | ATM (0.43) | ATMHTTALDH1A1MAPTKMT2A | |
| SCHEMBL15545351 | 0.73 | ATM (0.43) | ATMHTTALDH1A1MAPTKMT2A | |
| SCHEMBL20582641 | 0.70 | HTT (0.53) | HTTPKMALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870144-A1 | OREXIN RECEPTOR ANTAGONISTS | Heptares Therapeutics Limited (GB) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014006402-A1 | OREXIN RECEPTOR ANTAGONISTS | HEPTARES THERAPEUTICS LIMITED (GB) | 2014-01-09 | — | — | WO | disclosed |