Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 5/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842076 | 0.90 | FASN (0.65) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15543468 | 0.90 | FASN (0.57) | FASNOPRM1SIGMAR1CHRM1KDM1A | |
| SCHEMBL15581977 | 0.86 | FASN (0.43) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15543780 | 0.86 | FASN (0.51) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15582348 | 0.86 | FASN (0.45) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15543784 | 0.86 | FASN (0.50) | FASNOPRM1SIGMAR1HSD11B1ALDH1A1 | |
| SCHEMBL15544827 | 0.86 | FASN (0.49) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15543457 | 0.85 | FASN (0.49) | FASNOPRM1SIGMAR1HSD11B1ALDH1A1 | |
| SCHEMBL15543524 | 0.85 | FASN (0.49) | FASNOPRM1SIGMAR1HSD11B1CHRM1 | |
| SCHEMBL15544244 | 0.85 | FASN (0.49) | FASNOPRM1SIGMAR1HSD11B1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |