Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16683781 | 0.91 | MEN1 (0.44) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL15532888 | 0.91 | MEN1 (0.44) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL15533296 | 0.91 | GRIN2D (0.39) | MEN1KMT2AALDH1A1GRIN2DGRIN3B | |
| SCHEMBL21997787 | 0.91 | MEN1 (0.44) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL15532601 | 0.91 | GRIN2D (0.39) | MEN1KMT2AALDH1A1GRIN2DGRIN3B | |
| SCHEMBL15532220 | 0.91 | GRIN2D (0.39) | MEN1KMT2AALDH1A1GRIN2DGRIN3B | |
| SCHEMBL12687856 | 0.91 | MEN1 (0.44) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL15532934 | 0.91 | MEN1 (0.44) | MEN1KMT2AALDH1A1NPSR1HTT | |
| SCHEMBL4389248 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1GRIN2DGRIN3B | |
| SCHEMBL5933135 | 0.80 | GRIN2D (0.44) | MEN1KMT2AALDH1A1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846784-A1 | COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME | Yale University (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013170147-A1 | COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME | YALE UNIVERSITY (US) | 2013-11-14 | — | — | WO | disclosed |