Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RPA1 | P27694 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15545760 | 0.91 | MEN1 (0.55) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL18035703 | 0.90 | KMT2A (0.46) | KMT2AMEN1RXFP1MAPTEIF4E | |
| SCHEMBL15547477 | 0.89 | KMT2A (0.48) | KMT2AMEN1RXFP1MAPTEIF4E | |
| SCHEMBL16893498 | 0.89 | KMT2A (0.44) | KMT2AMEN1RXFP1MAPTEIF4E | |
| Hydrochloric Acid SCHEMBL16893531 | 0.88 | KMT2A (0.48) | KMT2AMEN1RXFP1MAPTEIF4E | |
| SCHEMBL18035674 | 0.85 | KMT2A (0.47) | KMT2AMEN1RXFP1MAPTEIF4E | |
| SCHEMBL15546009 | 0.85 | KMT2A (0.66) | KMT2AMEN1RXFP1MAPTEIF4E | |
| SCHEMBL15546529 | 0.83 | MEN1 (0.49) | KMT2AMEN1RXFP1MAPTEIF4E | |
| SCHEMBL16893474 | 0.81 | MEN1 (0.52) | KMT2AMEN1RXFP1MAPTHPGD | |
| SCHEMBL28819583 | 0.81 | KMT2A (0.50) | KMT2AMEN1RXFP1MAPTEIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875010-B1 | THIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | METABRAIN RES (FR) | 2016-08-31 | — | — | EP | claimed |
| EP-2875010-A1 | THIOPHENE DERIVATIVES USED IN THE TREATMENT OF DIABETES | Metabrain Research (FR) | 2015-05-27 | — | — | EP | claimed |
| WO-2014013181-A1 | THIOPHENE DERIVATIVES USED IN THE TREATMENT OF DIABETES | METABRAIN RESEARCH (FR) | 2014-01-23 | — | — | WO | claimed |