Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16893531 | 0.99 | KMT2A (0.48) | KMT2AMEN1RXFP1MAPTCTSD | |
| SCHEMBL15546196 | 0.91 | MEN1 (0.55) | KMT2AMEN1RXFP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL16893371 | 0.90 | MEN1 (0.54) | KMT2AMEN1RXFP1MAPTKDM4E | |
| SCHEMBL15545547 | 0.89 | KMT2A (0.49) | KMT2AMEN1RXFP1MAPTCTSD | |
| SCHEMBL18035703 | 0.88 | KMT2A (0.46) | KMT2AMEN1RXFP1MAPTCTSD | |
| SCHEMBL16893498 | 0.85 | KMT2A (0.44) | KMT2AMEN1RXFP1MAPTCTSD | |
| SCHEMBL18035674 | 0.85 | KMT2A (0.47) | KMT2AMEN1RXFP1MAPTCTSD | |
| SCHEMBL28819583 | 0.84 | KMT2A (0.50) | KMT2AMEN1RXFP1MAPTKDM4E | |
| SCHEMBL15546009 | 0.84 | KMT2A (0.66) | KMT2AMEN1RXFP1MAPTKDM4E | |
| SCHEMBL15546529 | 0.84 | MEN1 (0.49) | KMT2AMEN1RXFP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875010-B1 | THIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | METABRAIN RES (FR) | 2016-08-31 | — | — | EP | claimed |
| EP-2875010-A1 | THIOPHENE DERIVATIVES USED IN THE TREATMENT OF DIABETES | Metabrain Research (FR) | 2015-05-27 | — | — | EP | claimed |
| WO-2014013181-A1 | THIOPHENE DERIVATIVES USED IN THE TREATMENT OF DIABETES | METABRAIN RESEARCH (FR) | 2014-01-23 | — | — | WO | claimed |
| US-9777015-B2 | Useful thiophene derivatives in the treatment of diabetes | METABRAIN RESEARCH (FR) | 2017-10-03 | — | — | US | disclosed |
| EP-2875010-B1 | THIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | METABRAIN RES (FR) | 2016-08-31 | — | — | EP | disclosed |
| US-20150197530-A1 | USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES | METABRAIN RESEARCH (FR) | 2015-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197530-A1 | USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES | SLC5A2, SLC5A1, TPMT | KMT2A 4602/4885MEN1 4184/4885RXFP1 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.