Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | MMP12 | P39900 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.48 |
| ▸ | MMP16 | P51512 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646192 | 0.85 | KMT2A (0.52) | KDM4EALDH1A1HPGDMMP2MMP12 | |
| SCHEMBL16893495 | 0.83 | GRM6 (0.48) | KDM4EALDH1A1HPGDKMT2ATP53 | |
| SCHEMBL1520751 | 0.80 | KMT2A (0.71) | KDM4EALDH1A1MMP2MMP12MMP9 | |
| SCHEMBL5823015 | 0.80 | KMT2A (0.56) | KDM4EALDH1A1HPGDMMP2MMP9 | |
| SCHEMBL15546606 | 0.80 | KMT2A (0.53) | KDM4EALDH1A1HPGDKMT2ATP53 | |
| SCHEMBL14645421 | 0.78 | KMT2A (0.54) | KDM4EALDH1A1HPGDKMT2ATP53 | |
| SCHEMBL7076248 | 0.78 | SMN1; SMN2 (0.54) | KDM4EALDH1A1HPGDRXFP1PTGS2 | |
| SCHEMBL16904657 | 0.75 | RXFP1 (0.66) | KDM4EALDH1A1HPGDMMP2MMP12 | |
| SCHEMBL28052606 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HPGDMMP2MMP12 | |
| SCHEMBL5057664 | 0.75 | KMT2A (0.46) | KDM4EALDH1A1HPGDKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875010-B1 | THIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | METABRAIN RES (FR) | 2016-08-31 | — | — | EP | disclosed |
| EP-2875010-A1 | THIOPHENE DERIVATIVES USED IN THE TREATMENT OF DIABETES | Metabrain Research (FR) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014013181-A1 | THIOPHENE DERIVATIVES USED IN THE TREATMENT OF DIABETES | METABRAIN RESEARCH (FR) | 2014-01-23 | — | — | WO | disclosed |