Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALAD | P13716 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520751 | 0.84 | KMT2A (0.71) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL15546606 | 0.83 | KMT2A (0.53) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL15546178 | 0.80 | KDM4E (0.51) | KMT2ATP53ALOX15MAPK1RXFP1 | |
| SCHEMBL14646192 | 0.80 | KMT2A (0.52) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL2120265 | 0.79 | TP53 (0.42) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL14646244 | 0.78 | KMT2A (0.48) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL15546043 | 0.76 | KMT2A (0.46) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL14646143 | 0.76 | KMT2A (0.46) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL5057664 | 0.75 | KMT2A (0.46) | KMT2ATP53ALOX15MAPK1MAPT | |
| SCHEMBL14646123 | 0.75 | KMT2A (0.45) | KMT2ATP53ALOX15MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006088694-A1 | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |