Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.64 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.60 |
| ▸ | THRA | P10827 | 10/20 | 0.56 |
| ▸ | THRB | P10828 | 10/20 | 0.56 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15547324 | 0.92 | EGLN1 (0.59) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL1115849 | 0.92 | EGLN1 (0.77) | EGLN1EGLN2THRATHRBBBOX1 | |
| Water SCHEMBL15548472 | 0.91 | EGLN1 (0.75) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL15549510 | 0.91 | EGLN1 (0.75) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL15549041 | 0.91 | EGLN1 (0.75) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL522758 | 0.87 | EGLN1 (0.84) | EGLN1EGLN2THRATHRB | |
| SCHEMBL3915087 | 0.87 | EGLN1 (0.61) | EGLN1EGLN2THRATHRB | |
| SCHEMBL15547171 | 0.87 | EGLN1 (0.60) | EGLN1EGLN2THRATHRB | |
| SCHEMBL15548046 | 0.85 | EGLN2 (0.53) | EGLN1EGLN2THRATHRB | |
| SCHEMBL1115578 | 0.83 | EGLN1 (0.67) | EGLN1EGLN2THRATHRBBBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872487-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | Fibrogen, Inc. (US) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014014834-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN, INC. (US) | 2014-01-23 | — | — | WO | disclosed |