SCHEMBL3915087

SCHEMBL3915087

O=C(O)CNC(=O)c1ncc2cc(Oc3ccc(C(F)(F)F)cc3)ccc2c1CO

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 14/20 0.61
EGLN2 Q96KS0 6/20 0.49
THRA P10827 8/20 0.48
THRB P10828 8/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1115849 0.89 EGLN1 (0.77) EGLN1EGLN2THRATHRB
SCHEMBL523875 0.88 EGLN1 (0.79) EGLN1EGLN2THRATHRB
SCHEMBL15549041 0.88 EGLN1 (0.75) EGLN1EGLN2THRATHRB
SCHEMBL15549510 0.88 EGLN1 (0.75) EGLN1EGLN2THRATHRB
Water SCHEMBL15548472 0.88 EGLN1 (0.75) EGLN1EGLN2THRATHRB
SCHEMBL15547656 0.87 EGLN1 (0.64) EGLN1EGLN2THRATHRB
SCHEMBL15547171 0.86 EGLN1 (0.60) EGLN1EGLN2THRATHRB
SCHEMBL522574 0.82 EGLN1 (0.66) EGLN1EGLN2THRATHRB
SCHEMBL27755793 0.82 EGLN1 (0.66) EGLN1EGLN2THRATHRB
SCHEMBL1115578 0.81 EGLN1 (0.67) EGLN1EGLN2THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893186-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2008-03-05 EP claimed
WO-2006133391-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2006-12-14 WO claimed
EP-2035000-A1 HIF HYDROXYLASE INHIBITORS FOR TREATMENT OF ANEMIA OF CANCER FIBROGEN, INC. (US) 2009-03-18 EP disclosed
EP-1991269-A1 COMPOUNDS AND METHODS FOR TREATMENT OF STROKE FIBROGEN, INC. (US) 2008-11-19 EP disclosed
WO-2007146438-A1 HIF HYDROXYLASE INHIBITORS FOR TREATMENT OF ANEMIA OF CANCER FIBROGEN, INC. (US) 2007-12-21 WO disclosed
WO-2007097929-A1 COMPOUNDS AND METHODS FOR TREATMENT OF STROKE FIBROGEN, INC. (US) 2007-08-30 WO disclosed
WO-2007047194-A2 METHODS FOR TREATING MITF-RELATED DISORDERS DANA-FARBER CANCER INSTITUTE, INC. (US) 2007-04-26 WO disclosed
EP-1644336-A1 NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN FIBROGEN, INC. (US) 2006-04-12 EP disclosed
WO-2004108681-A1 NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN FIBROGEN, INC. (US) 2004-12-16 WO disclosed