Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.46 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29732854 | 0.83 | CAMKK2 (0.46) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL1384475 | 0.83 | CAMKK2 (0.46) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL28098788 | 0.83 | MAP2K1 (0.41) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL1048847 | 0.81 | KDM4E (0.47) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL29623160 | 0.81 | KDM4E (0.47) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL5924436 | 0.80 | MAP2K1 (0.43) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL5924295 | 0.80 | KDM4E (0.40) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL5924485 | 0.79 | KDM4E (0.40) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19997255 | 0.79 | GSK3A (0.45) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL4667694 | 0.78 | CAMKK2 (0.39) | KDM4EMAPK10HSD17B10ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488519-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | Pierre Fabre Médicament (FR) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045344-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | PIERRE FABRE MEDICAMENT (FR) | 2011-04-21 | — | — | WO | disclosed |